Transperineal implantation of Hialuronic Ácid in the anterior perirectal fat as protector to the rectal wall from radiation delivered with either intensity modulated brachytherapy or EBRT for prostate cancer patients

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Prada PJ., Martinez A., Fernandez J, .et al. Transperineal implantation of Hialuronic Ácid in the anterior perirectal fat as protector to the rectal wall from radiation delivered with either intensity modulated brachytherapy or EBRT for prostate cancer patients. 27th Annual Meeting Brachytherapy Society (ABS). Philadelphia, May 2006. Acute and chronic rectal toxicity remain one of the complications affecting quality of life for those patients with intermediate and high risk prostate cancer treated to high doses with radiotherapy. Most series report 1-2% for rectal ulcers, rectal proctitis grade 1-3 between 2-17%, and rectal bledding up to 20%. In an effort to decrease these complications, we began a clinical trial approved by the HIC of Asturias University injecting hyaluronic acid in the perirectal fat to increase the distance between the posterior prostate capsule and the anterior rectal wall.